Methanol → 2,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid

HRID 2419015

反応式

HRID 2419015 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]2[O:12][CH2:13][O:14][C:9]2=[CH:8][C:3]=1[C:4]([O:6]C)=O.Cl[C:16]1[N:24]=[CH:23][CH:22]=[CH:21][C:17]=1[C:18]([OH:20])=[O:19].CO>CN(C=O)C>[CH2:13]1[O:12][C:10]2[CH:11]=[C:2]3[C:3]([C:4](=[O:6])[N:24]4[CH:23]=[CH:22][CH:21]=[C:17]([C:18]([OH:20])=[O:19])[C:16]4=[N:1]3)=[CH:8][C:9]=2[O:14]1

参加物

5

反応物 3

HCID 887MethanolHCID 762582-Chloronicotinic acidHCID 290838Methyl 6-amino-1,3-benzodioxole-5-carboxylate

生成物 1

HCID 203168392,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2.00g (10.4 mmol) of methyl 2-amino-4,5-methylenedioxybenzoate, 1.67g (10.4 mmol) of 2-chloronicotinic acid and 50mg of KI was heated at 170° for 1 hour. The fusion or melt gradually solidified to an orange cake. The solid material was heated in boiling methanol (250 ml) and then filtered to yield 1.60g of crude product, mp. 273°-280° dec. The analytical sample was obtained by recrystallization from DMF, mp. 300°-304° dec.

後処理

  1. temperaturewas heated at 170° for 1 hour
  2. temperatureThe solid material was heated
  3. filtrationfiltered
  4. customto yield 1.60g of crude product, mp. 273°-280° dec

出典と根拠

ORDレコード
ord-6c4ebe5621724a688721fa60eaf7865f
出典データセット
uspto-grants-1978_08
特許番号
US04104389

関連ノート

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