Water → 4-(Pyridin-2-yl)butan-1-amine
反応式
[C:1]([CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1参加物
6
実験手順
2-(3-cyanopropyl)pyridine (14.6 g) in dry ether (100 ml) is added dropwise to a stirred suspension of lithium aluminium hydride (9.5 g) in dry ether (300 ml). The mixture is heated under reflux for 3 hours, cooled and treated successively with water, aqueous sodium hydroxide and water. Extraction with chloroform, followed by fractionation affords 2-(4-aminobutyl)pyridine (6.7 g), b.p. 100°-101° C./1.0 mm.
後処理
- temperatureThe mixture is heated
- temperatureunder reflux for 3 hours
- temperaturecooled
- extractionExtraction with chloroform
出典と根拠
- ORDレコード
- ord-acbd0e9ad9d5418c8a540e38b836c481
- 出典データセット
- uspto-grants-1978_08
- 特許番号
- US04104382
反応ノート
読み込み中…