Mesityl oxide → 2-Oxo-2-ethoxy-3,3,5-trimethyl-5-diethylphosphono-1,2-oxaphospholane

HRID 2419169ノート

反応式

HRID 2419169 の反応式
C[C:2]([P:8]([O:13][CH2:14][CH3:15])([O:10][CH2:11][CH3:12])=[O:9])([CH3:7])[CH2:3][C:4](=O)[CH3:5].O=[C:17](C=C(C)C)C.[P:23]([O-:30])([O:27]CC)[O:24][CH2:25][CH3:26].[O-]CC.[Na+]>>[O:27]=[P:23]1([O:24][CH2:25][CH3:26])[C:4]([CH3:5])([CH3:17])[CH2:3][C:2]([CH3:7])([P:8]([O:10][CH2:11][CH3:12])([O:13][CH2:14][CH3:15])=[O:9])[O:30]1

参加物

5

反応物 4

HCID 8858Mesityl oxideHCID 2723922Sodium ethoxide2 回HCID 3780918Diethylphosphite2 回HCID 153111314-Methyl-4-diethylphosphonopentan-2-one

生成物 1

HCID 544345382-Oxo-2-ethoxy-3,3,5-trimethyl-5-diethylphosphono-1,2-oxaphospholane

実験手順

To a mixture of 2.36 grams (10 m moles) of 4-methyl-4-diethylphosphonopentan-2-one (prepared from 1 mole of mesityl oxide and 1 mole of diethyl phosphite by the procedure of A. N. Pudovik, Zhurn Obshch. Khim., 22, 1371 (1952) and 1.64 grams (11.9 m moles) of diethyl phosphite was added 0.30 gram of ethanolic sodium ethoxide solution containing 0.75 m moles of sodium ethoxide. A spontaneous exothermic reaction took place immediately. After 5 minutes the reaction mixture was analyzed by gas phase chromatography and was shown to contain over 70% of the desired 2-oxo-2-ethoxy-3,3,5-trimethyl-5-diethyl-phosphono-1,2-oxaphospholane. The product was then isolated by vacuum distillation as described in Example 3.

後処理

  1. customA spontaneous exothermic reaction
  2. customThe product was then isolated by vacuum distillation

出典と根拠

ORDレコード
ord-8a921a5a08a4497498bc7debdc5ecf63
出典データセット
uspto-grants-1978_08
特許番号
US04105630

反応ノート

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