Glyoxylic Acid → (2-Chloroacetamido)(hydroxy)acetic acid

反応式

[C:1]([OH:5])(=[O:4])[CH:2]=[O:3].[Cl:6][CH2:7][C:8]([NH2:10])=[O:9]>>[Cl:6][CH2:7][C:8]([NH:10][CH:2]([OH:3])[C:1]([OH:5])=[O:4])=[O:9]

参加物

反応物 2

HCID 760Glyoxylic Acid

HCID 6580Chloroacetamide

生成物 1

HCID 23257102(2-Chloroacetamido)(hydroxy)acetic acid収率 69%

反応条件

温度: 50 °C

実験手順

740 g of an aqueous solution with 50% of glyoxylic acid (5 moles) are mixed with 514 g of chloracetamide (5.5 moles). The mixture is heated to 50° C, then the greater part of the water is removed under vacuum, 1200 g of acetic acid are added and it is cooled on ice. After filtration and drying, 475 g of product are obtained. The product concentrated under vacuum gives 112 g of a second crop, namely a total yield of 69%.

後処理

customthe greater part of the water is removed under vacuum, 1200 g of acetic acid
additionare added
temperatureit is cooled on ice
filtrationAfter filtration
customdrying

出典と根拠

ORDレコード: ord-deffc90884024958a8c8eb1439e4e673
出典データセット: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04105690

反応ノート

読み込み中…

参加物