3-Nitro 6-(2-pyridylthio) imidazo [1,2-a] pyridine → 3-Amino-6-(2-pyridylthio) imidazo [1,2-a] pyridine

HRID 2419317ノート

反応式

HRID 2419317 の反応式
[N+:1]([C:4]1[N:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:11]=[CH:12][C:7]2=[N:6][CH:5]=1)([O-])=O.[H][H]>[Pd].O1CCOCC1>[NH2:1][C:4]1[N:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:11]=[CH:12][C:7]2=[N:6][CH:5]=1

参加物

5

反応物 2

HCID 538630633-Nitro 6-(2-pyridylthio) imidazo [1,2-a] pyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 542000433-Amino-6-(2-pyridylthio) imidazo [1,2-a] pyridine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 0.542 gm. (0.002 mole) of 3-nitro-6-(2-pyridylthio) imidazo [1,2-a] pyridine in 20 ml. of dioxane is reduced at 40 psi. under a hydrogen atmosphere with 0.500 g. of 5% palladium on carbon as catalyst. When the uptake of hydrogen is complete, the catalyst is removed by filtration. The filtrate is evaporated in vacuo to yield 3-amino-6-(2-pyridylthio) imidazo [1,2-a] pyridine.

後処理

  1. customthe catalyst is removed by filtration
  2. customThe filtrate is evaporated in vacuo

出典と根拠

ORDレコード
ord-967c8f69950643039b2a69ede23bb25c
出典データセット
uspto-grants-1978_08
特許番号
US04105767

反応ノート

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