Methanol → Methyl 4-(aminoacetyl)phenoxyacetate hydrochloride

HRID 2419364ノート

反応式

HRID 2419364 の反応式
S(Cl)([Cl:3])=O.Cl.[NH2:6][CH2:7][C:8]([C:10]1[CH:20]=[CH:19][C:13]([O:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1)=[O:9].[CH3:21]O>>[ClH:3].[NH2:6][CH2:7][C:8]([C:10]1[CH:11]=[CH:12][C:13]([O:14][CH2:15][C:16]([O:18][CH3:21])=[O:17])=[CH:19][CH:20]=1)=[O:9]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 145369464-(Aminoacetyl)phenoxyacetic acid hydrochloride

生成物 1

HCID 20315552Methyl 4-(aminoacetyl)phenoxyacetate hydrochloride収率 62%

実験手順

Methanol (250ml.) was stirred at -20° C. as thionyl chloride (6ml.) was added. 4-(Aminoacetyl)phenoxyacetic acid hydrochloride (5.0g) was added, and the mixture was stirred and allowed to warm to room temperature during 18 hours. The resulting solution was evaporated under reduced pressure and the residue was recrystallised from a mixture of methanol and diethyl ether to give methyl 4-(aminoacetyl)-phenoxyacetate hydrochloride, m.p. 202°-204° C. (Example 12) in 62% yield.

後処理

  1. additionwas added
  2. customThe resulting solution was evaporated under reduced pressure
  3. customthe residue was recrystallised from a mixture of methanol and diethyl ether

出典と根拠

ORDレコード
ord-800387dbdf12442491dfbf59280641f7
出典データセット
uspto-grants-1978_08
特許番号
US04105790

反応ノート

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