Trimethylsilyl iodide → HCID 178481766、化合物
反応式
C[O:2][C:3]1[CH:8]=[C:7]([C:9]2[N:14]=[C:13]3[N:15]([CH3:18])[N:16]=[CH:17][C:12]3=[C:11]([O:19][C:20]3[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][CH:21]=3)[CH:10]=2)[CH:6]=[CH:5][N:4]=1.I[Si](C)(C)C>C(#N)C>[CH3:18][N:15]1[C:13]2=[N:14][C:9]([C:7]3[CH:6]=[CH:5][N:4]=[C:3]([OH:2])[CH:8]=3)=[CH:10][C:11]([O:19][C:20]3[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][CH:21]=3)=[C:12]2[CH:17]=[N:16]1参加物
4
反応条件
- 温度
- 70 °C
実験手順
To 6-(2-methoxypyridin-4-yl)-1-methyl-4-(4-(methylsulfonyl)phenoxy)-1H-pyrazolo[3,4-b]pyridine 118 (100 mg) in acetonitrile (1 mL) was added iodotrimethylsilane (140 μl). The resulting mixture was heated 3 h at 70° C. and purified by reverse phase HPLC to provide 120. MS (ESI) m/z 397.1 (M+1)+