[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]([NH:8][C:9]1[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][C:10]=1[C:11]([O:13]C)=O)=[O:7])[CH3:2].CCOCC.CC[O-].[Na+].[Na]>C(O)C>[OH:7][C:6]1[C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:23])=[C:11]([OH:13])[C:10]2[C:9](=[C:18]([C:19]([F:22])([F:21])[F:20])[CH:17]=[CH:16][CH:15]=2)[N:8]=135.66 g of the product of Step B were added to 800 ml of anhydrous ether in the presence of sodium ethylate prepared from 2.69 g of sodium and 54 ml of ethanol and the mixture was vacuum filtered. The recovered precipitate was dissolved in water and the pH of the solution was adjusted to 1 by addition of 20% hydrochloric acid to obtain 30.56 g of ethyl 2,4-dihydroxy-8-trifluoromethyl-quinoline-3-carboxylate melting at 190° C which was used as is for the next step.
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