L-Alanine → Leucyl-alanyl-glycyl-valine

反応式

[NH2:1][C@H:2]([C:7]([OH:9])=O)[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:10][C@H:11]([C:13]([OH:15])=O)[CH3:12].[NH2:16][C@H:17]([C:21]([OH:23])=[O:22])[CH:18]([CH3:20])[CH3:19]>>[NH2:1][C@H:2]([C:7]([NH:10][C@H:11]([C:13]([NH:1][CH2:2][C:7]([NH:16][C@H:17]([C:21]([OH:23])=[O:22])[CH:18]([CH3:20])[CH3:19])=[O:9])=[O:15])[CH3:12])=[O:9])[CH2:3][CH:4]([CH3:5])[CH3:6]

参加物

反応物 3

HCID 5950L-Alanine

HCID 6106L-Leucine2 回

HCID 6287L-Valine

生成物 1

HCID 152207Leucyl-alanyl-glycyl-valine

実験手順

The completed Boc-tetrapeptide resin was subjected to steps (1) and (2) to cleave the Boc group and worked up as described for (A) to yield 707 mg of peptide resin. Amino acid analysis: Gly 1.05, Ala 1.00, Val 1.12, Leu 1.05.

出典と根拠

ORDレコード: ord-2f0d1be5949d48eea239a4bd8cbc9854
出典データセット: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04108846

反応ノート

読み込み中…