Thionyl Chloride → Pseudosaccharin chloride

HRID 2419998

反応式

HRID 2419998 の反応式
[S:1]1(=[O:11])(=[O:10])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[N:2]1.S(Cl)([Cl:14])=O.O1CCOCC1>CN(C)C=O>[Cl:14][C:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1](=[O:10])(=[O:11])[N:2]=1

参加物

5

反応物 3

HCID 24386Thionyl Chloride2 回HCID 312751,4-DioxaneHCID 130862071H-1lambda~6~,2-Benzothiazole-1,1-dione

生成物 1

HCID 64783Pseudosaccharin chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

100 g (545 mM) of benzisothiazole-1,1-dioxide 100 ml. of thionyl chloride, 4 ml. of dimethylformamide (catalyst) and 400 ml. of dioxane are refluxed overnight. Thionyl chloride (50 ml.) and dimethylformamide (1 ml.) are added to the reaction mixture which is again refluxed overnight. The reaction mixture is evaporated to dryness and the residue recrystallized from toluene to obtain 73.4 g of 3-chloro-1,2-benzisothiazole-1,1-dioxide, m.p. 140°-145°.

後処理

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue recrystallized from toluene

出典と根拠

ORDレコード
ord-04b913fb6bf6417b9da2b894a1c6d41a
出典データセット
uspto-grants-1978_08
特許番号
US04108860

関連ノート

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