Hydrochloric Acid → 2-Carboxy-3-methyl-5,6-dihydro-1,4-dithiin

HRID 2420127

反応式

HRID 2420127 の反応式
C([O:3][C:4]([C:6]1[S:11][CH2:10][CH2:9][S:8][C:7]=1[CH3:12])=[O:5])C.[OH-].[K+].Cl>CO>[C:4]([C:6]1[S:11][CH2:10][CH2:9][S:8][C:7]=1[CH3:12])([OH:5])=[O:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 12368330Ethyl 3-methyl-5,6-dihydro-1,4-dithiine-2-carboxylate

生成物 1

HCID 6005022-Carboxy-3-methyl-5,6-dihydro-1,4-dithiin

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-Ethoxycarbonyl-2-methyl-5,6-dihydro-1,4-dithiin (10.0 g.) is heated at reflux for eight hours in a solution of potassium hydroxide (85%; 3.60 g.) in methanol (40 ml.). The cool solution is acidified wth 10% aqueous hydrochloric acid and the precipitate is removed by filtration and dried (8.1 g.). The crude product is recrystallized from ethanol to afford 2-carboxy-3-methyl-5,6-dihydro-1,4-dithiin, m.p. 179°-180° C., dec.

後処理

  1. customthe precipitate is removed by filtration
  2. customdried (8.1 g.)
  3. customThe crude product is recrystallized from ethanol

出典と根拠

ORDレコード
ord-70e4d169155a4e7c915561bf3de09c9b
出典データセット
uspto-grants-1978_08
特許番号
US04109006

関連ノート

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