2-Methylbenzenesulfonic acid → HCID 20311044、化合物

HRID 2420186ノート

反応式

HRID 2420186 の反応式
[CH:1]([N:4]([CH2:9][CH:10]([O:14]CC)[O:11][CH2:12]C)[C:5](=[O:8])[CH2:6][Cl:7])([CH3:3])[CH3:2].[C:17]1([CH3:27])[C:18](S(O)(=O)=O)=[CH:19]C=C[CH:22]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH:1]([N:4]([CH2:9][CH:10]1[O:11][CH2:12][CH:18]([CH3:19])[CH:17]([CH3:27])[CH2:22][O:14]1)[C:5](=[O:8])[CH2:6][Cl:7])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 69252-Methylbenzenesulfonic acidHCID 10340Sodium CarbonateHCID 22768137HCID 22768137、化合物

生成物 1

HCID 20311044HCID 20311044、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

N-Isopropyl-N-(2,2-diethoxyethyl)-α-chloroacetamide (10 grams), 2,3-dimethylbutandiol-1,4 (4.5 grams) and trace amounts of toluenesulfonic acid are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated until no more ethanol is given off. After this time sodium carbonate (1 gram) is added to the mixture with stirring and the resulting mixture is distilled to yield the desired product N-isopropyl-N-(5,6-dimethyl-1,3-dioxepan-2-ylmethyl)-α-chloroacetamide as an oil.

後処理

  1. additionare charged into a glass reaction vessel
  2. customequipped with a mechanical stirrer
  3. temperaturethermometer and reflux condenser
  4. distillationthe resulting mixture is distilled

出典と根拠

ORDレコード
ord-2f1e540daec14140b7a64f41addb4895
出典データセット
uspto-grants-1978_08
特許番号
US04110101

反応ノート

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