Acetone → N-(3,5-Dichloro-2-hydroxy-4-methylphenyl)acetamide

HRID 2420206

反応式

HRID 2420206 の反応式
Cl.[NH2:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([CH3:10])=[C:5]([Cl:11])[C:4]=1[OH:12].C(N(CC)C1C=CC=CC=1)C.[CH3:24][C:25](C)=[O:26].C(Cl)(=O)C>O>[C:25]([NH:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([CH3:10])=[C:5]([Cl:11])[C:4]=1[OH:12])(=[O:26])[CH3:24]

参加物

6

反応物 4

HCID 180AcetoneHCID 6367Acetyl chlorideHCID 7061N,N-DiethylanilineHCID 1702236-Amino-2,4-dichloro-m-cresol hydrochloride

生成物 1

HCID 13796880N-(3,5-Dichloro-2-hydroxy-4-methylphenyl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of 68.4 g. of 2-amino-5-methyl-4,6-dichloro-phenol hydrochloride and 96 ml. of N,N-diethylaniline in 750 ml. of acetone, 23.4 ml. of acetyl chloride were added slowly by keeping the temperature under 20° C. At the end, the reaction mixture was heated to reflux for an hour. After cooling, the solution was poured into water; the solid product, thus obtained, was collected on a buckner, washed with water until the washings were neutral and dried in a desicator at 50° C. The raw product obtained was purified by crystallization from ethyl alcohol, yielding 44 g. of a pure product with M.P. = 175°-176.5° C.

後処理

  1. additionTo a mixture of 68.4 g
  2. customunder 20° C
  3. temperatureAt the end, the reaction mixture was heated
  4. temperatureto reflux for an hour
  5. temperatureAfter cooling
  6. customthe solid product, thus obtained
  7. customwas collected on a buckner
  8. washwashed with water until the washings
  9. customdried in a desicator at 50° C

出典と根拠

ORDレコード
ord-276cb44cd9e64c2f9dbd148d277632b1
出典データセット
uspto-grants-1978_08
特許番号
US04110116

関連ノート

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