Ethanol → HCID 20186934、化合物

反応式

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=O)=[CH:2]1.[C-]#[N:13].[K+].[CH2:15]([OH:17])C.O.C[N:20]([CH:22]=[O:23])C>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[NH:13][C:22](=[O:23])[NH:20][C:15]2=[O:17])=[CH:2]1

参加物

反応物 5

HCID 702Ethanol

HCID 962Water

HCID 6228Dimethylformamide

HCID 9032Potassium Cyanide

HCID 10256Indole-3-Carboxaldehyde

生成物 1

HCID 20186934HCID 20186934、化合物

実験手順

A mixture of indole-3-carboxaldehyde (43.6 g, 0.3 mole), KCN (29.3 g, 0.45 mole), (NH4)2CO3 (144 g, 1.5 mole), 250 ml of C2H5OH, 250 ml of H2O and 200 ml of DMF was warmed with stirring at 70°-80° for 16 hours. The dark solution was filtered, cooled and acidified with concentrated HCl. The solid was collected, dissolved in dilute NaOH, filtered and acidified with dilute HCl. The solid was collected and recrystallized from aqueous methanol, yield 28.5 g, mp 229°-30°.