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5-(1h-Indol-3-ylmethyl)imidazolidine-2,4-dione → 5-[(Indol-3-yl)methyl]-3-(3-morpholinopropyl)hydantoin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(1h-Indol-3-ylmethyl)imidazolidine-2,4-dione | HCID 242867 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-[(Indol-3-yl)methyl]-3-(3-morpholinopropyl)hydantoin | HCID 20312115 | — |
反応手順
5-[(Indol-3-yl)methyl]hydantoin (5 g; 0.022 mole) was added to NaOC2H5 (0.022 mole) in 300 ml of anhydrous C2H5OH. The first mixture was heated to reflux, and 1-(3-chloropropyl)-morpholine (3.5 g, 0.022 mole) was added. The mixture was heated for 6 hours and then diluted with H2O. The solid was collected and recrystallized from 2-propanol-petroleum ether, yield 3 g, mp 158°-60°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04110536 |
| 出典データセット | uspto-grants-1978_08 |
| ORD ID | ord-fc4cb6b5a44f4c1c8f3999b6c49a33b3 |
| 出典メモ | uspto-grants-1978_08 |