反应详情

5-[(Indol-3-yl)methyl]hydantoin (5 g; 0.022 mole) was added to NaOC2H5 (0.022 mole) in 300 ml of anhydrous C2H5OH. The first mixture was heated to reflux, and 1-(3-chloropropyl)-morpholine (3.5 g, 0.022 mole) was added. The mixture was heated for 6 hours and then diluted with H2O. The solid was collected and recrystallized from 2-propanol-petroleum ether, yield 3 g, mp 158°-60°.

1. temperatureThe first mixture was heated
2. temperatureto reflux
3. temperatureThe mixture was heated for 6 hours
4. customThe solid was collected
5. customrecrystallized from 2-propanol-petroleum ether, yield 3 g, mp 158°-60°