Ethanol → 5-ethoxy-8-ethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e]-[1,2,4]triazolo[1,5-a]pyrimidine

HRID 2420578ノート

反応式

HRID 2420578 の反応式
Cl[C:2]1[C:7]2[CH:8]=[N:9][C:10]3[N:14]([CH2:15][CH3:16])[N:13]=[CH:12][C:11]=3[C:6]=2[N:5]2[N:17]=[CH:18][N:19]=[C:4]2[N:3]=1.[Na].[CH2:21]([OH:23])[CH3:22]>>[CH2:21]([O:23][C:2]1[C:7]2[CH:8]=[N:9][C:10]3[N:14]([CH2:15][CH3:16])[N:13]=[CH:12][C:11]=3[C:6]=2[N:5]2[N:17]=[CH:18][N:19]=[C:4]2[N:3]=1)[CH3:22]

参加物

4

反応物 3

HCID 702EthanolHCID 5360545SodiumHCID 227584865-Chloro-8-ethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]-triazolo[1,5-a]pyrimidine

生成物 1

HCID 227585245-ethoxy-8-ethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e]-[1,2,4]triazolo[1,5-a]pyrimidine

実験手順

2.7 g. of 5-chloro-8-ethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine of Example 1 (b) (0.01 mol.) are added with stirring to a solution of 2.3 g. of sodium in 50 ml. of dry ethanol. The mixture is stirred at room temperature for 6 hours. The precipitate is filtered off, washed with water and recrystallized from ethanol to obtain 5-ethoxy-8-ethyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine, yield 2.1 g. (74%); m.p. 196°-197°.

後処理

  1. stirringThe mixture is stirred at room temperature for 6 hours
  2. filtrationThe precipitate is filtered off
  3. washwashed with water
  4. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-938e60077de14901a3c0cae419265e54
出典データセット
uspto-grants-1978_08
特許番号
US04110454

反応ノート

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