N-bromobutanimide → Ethyl 6-oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylate

HRID 2421030ノート

反応式

HRID 2421030 の反応式
[O:1]=[C:2]1[NH:7][C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])=[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:4][CH2:3]1.BrN1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[O:1]=[C:2]1[NH:7][C:6]([C:8]([F:13])([F:14])[C:9]([F:10])([F:11])[F:12])=[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:4]=[CH:3]1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 86611248Ethyl 6-oxo-2-(pentafluoroethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate

生成物 1

HCID 86611249Ethyl 6-oxo-2-(pentafluoroethyl)-1,6-dihydropyridine-3-carboxylate収率 43.8%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

反応条件

温度
80 °C

実験手順

A suspension of ethyl 6-oxo-2-(pentafluoroethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate (0.690 g) and N-bromosuccinimide (0.427 g) in carbon tetrachloride (5 mL) was heated at 80° C. for 20 h. The reaction mixture was concentrated in vacuo and subjected to flash column chromatography (eluent 1:3 ethyl acetate/isohexane) to yield a colourless solid (0.30 g).

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-885a408ad58b46549dc94731e4f37375
出典データセット
uspto-grants-2011_06
特許番号
US07956070B2

反応ノート

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