反応式
[F:1][C:2]1[CH:3]=[C:4]([N:17]2[C:25]3[C:20](=[C:21]([O:26]CC4C=CC=CC=4)[CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18]2)[CH:5]=[C:6]([F:16])[C:7]=1[O:8]CC1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[F:16][C:6]1[CH:5]=[C:4]([N:17]2[C:25]3[CH:24]=[CH:23][CH:22]=[C:21]([OH:26])[C:20]=3[CH:19]=[CH:18]2)[CH:3]=[C:2]([F:1])[C:7]=1[OH:8]参加物
4
実験手順
1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole (D21) (299 mg, 0.678 mmoL) was dissolved in ethyl acetate (10 mL) and was hydrogenated at room temperature and atmospheric pressure in the presence of 10% palladium on charcoal (50% wet) (150 mg). After 21 hours the mixture was filtered and concentrated in vacuo. The crude product was purified by flash chromatography (Biotage SP4) eluting with a gradient of 0 to 100% Et2O in hexane to give the title compound (E11), (61 mg).
後処理
- customwas hydrogenated at room temperature
- filtrationAfter 21 hours the mixture was filtered
- concentrationconcentrated in vacuo
- customThe crude product was purified by flash chromatography (Biotage SP4)
- washeluting with a gradient of 0 to 100% Et2O in hexane
出典と根拠
- ORDレコード
- ord-9e4f8a5d2a2f4b4d9194426256e2f22a
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07956083B2
関連ノート
読み込み中…