Thionyl Chloride → 4-(Chloromethyl)-N-(4-fluorophenyl)-6-methylpyrimidine-2-amine
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[C:13]([CH2:15]O)[CH:12]=[C:11]([CH3:17])[N:10]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>ClCCl>[Cl:20][CH2:15][C:13]1[CH:12]=[C:11]([CH3:17])[N:10]=[C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[N:14]=1参加物
4
実験手順
At 0° C., 225 mg (0.96 mmol) of the compound from example 6A and 137 mg (1.16 mmol) of thionyl chloride are initially charged in 10 ml of dichloromethane and, after warming to RT, stirred at this temperature for 24 h. The solvent is removed on a rotary evaporator and the product that remains is directly reacted further.
後処理
- customThe solvent is removed on a rotary evaporator
- customthe product that remains is directly reacted further
出典と根拠
- ORDレコード
- ord-4600fafe061d4f6399db50d26ec7e638
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08653109B2
反応ノート
読み込み中…