Ethanol → N-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine hydrobromide

HRID 2422251ノート

反応式

HRID 2422251 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=O.[CH2:15]([NH:18][C:19]([NH2:21])=[S:20])[CH2:16][CH3:17].C(O)C>C(OC(C)C)(C)C>[BrH:1].[CH2:15]([NH:18][C:19]1[S:20][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=2)[N:21]=1)[CH2:16][CH3:17]

参加物

5

反応物 3

HCID 702EthanolHCID 3219792-Bromo-4'-(trifluoromethyl)acetophenoneHCID 1615208Propyl-2-thiourea

生成物 1

HCID 23082954N-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine hydrobromide収率 70%

試薬・触媒・溶媒 1

HCID 7914Diisopropyl Ether溶媒

実験手順

A mixture of 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (5.34 g), N-propylthiourea (2.60 g) and ethanol (50 mL) was stirred for 1 hr while heating under reflux. The reaction mixture was cooled and diluted with isopropyl ether. The precipitated solid was collected by filtration, washed with isopropyl ether and dried to give the title compound (5.11 g, yield 70%) as colorless crystals.

後処理

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe precipitated solid was collected by filtration
  5. washwashed with isopropyl ether
  6. customdried

出典と根拠

ORDレコード
ord-be129a25c75a4a96a67dd0170d5191f1
出典データセット
uspto-grants-2011_06
特許番号
US07960369B2

反応ノート

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