Ethanol → 3-(4-Hydroxyphenyl)-propionic acid tert-butyl ester

HRID 2422262ノート

反応式

HRID 2422262 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1.C(O)C>[Pd].[C].O1CCCC1>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:13][CH:14]=1

参加物

5

反応物 2

HCID 702EthanolHCID 15480691HCID 15480691、化合物

生成物 1

HCID 121124243-(4-Hydroxyphenyl)-propionic acid tert-butyl ester収率 79%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of tert-butyl (2E)-3-[4-(benzyloxy)phenyl]acrylate (13.3 g, 42.8 mmol), 10% Pd carbon (1.3 g), ethanol (100 mL) and tetrahydrofuran (30 mL) was stirred under a hydrogen atmosphere for 2 hrs. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (7.5 g, yield 79%) as colorless crystals.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-b4396e01e13f457b93c717e31eb81cde
出典データセット
uspto-grants-2011_06
特許番号
US07960369B2

反応ノート

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