Sodium borohydride → (6-o-Tolylpyridin-3-yl)methanol

HRID 2422367ノート

反応式

HRID 2422367 の反応式
[C:1]1([CH3:15])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[O:12])=[CH:9][N:8]=1.[BH4-].[Na+]>C(O)C>[C:1]1([CH3:15])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:8]=[CH:9][C:10]([CH2:11][OH:12])=[CH:13][CH:14]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 247296626-(2-Methylphenyl)pyridine-3-carbaldehyde

生成物 1

HCID 24729916(6-o-Tolylpyridin-3-yl)methanol収率 100%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 1.070 g (5.43 mmol) of 6-o-tolylnicotinaldehyde in 19 mL of ethanol at 0-5° C., was added 287 mg (7.5 mmol, 1.4 eq.) of sodium borohydride. After 2 h, the reaction mixture was quenched with saturated sodium bicarbonate solution and, after 30 min, partitioned between dichloromethane and brine. The organic extract was dried over magnesium sulfate and concentrated to give the indicated product as a colorless oil, 1.08 g, 100% yield.

後処理

  1. customthe reaction mixture was quenched with saturated sodium bicarbonate solution and, after 30 min
  2. custompartitioned between dichloromethane and brine
  3. extractionThe organic extract
  4. dry with materialwas dried over magnesium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-aa2d1c13fbc744e18f8a5e55435d2a3a
出典データセット
uspto-grants-2011_06
特許番号
US07960349B2

反応ノート

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