Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 242240ノート

反応式

HRID 242240 の反応式
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.Cl.[OH:10][CH:11]1[CH2:14][NH:13][CH2:12]1.[OH-].[Na+]>O>[Cl:8][C:6]1[N:7]=[CH:2][N:3]=[C:4]([N:13]2[CH2:14][CH:11]([OH:10])[CH2:12]2)[CH:5]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 775312,4-Dichloropyrimidine2 回HCID 27592903-Hydroxyazetidine hydrochloride

生成物 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-ol収率 115.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

7.2 g (48.7 mmol) 2,4-dichloropyrimidine are initially introduced into 140 ml water. 5.3 g (48.7 mmol) 3-hydroxyazetidine hydrochloride and 48.7 ml 1 N sodium hydroxide solution are added and the mixture is heated at 90° C. for 72 h (the 2,4-dichloropyrimidine being detectably volatile and precipitating in crystalline form on the condenser). The solvent is removed in vacuo and the residue is dried to give 10.4 g of the crude product, which is reacted without further purification.

後処理

  1. customprecipitating in crystalline form on the condenser)
  2. customThe solvent is removed in vacuo
  3. customthe residue is dried

出典と根拠

ORDレコード
ord-ddae72d83b7742eca25dab5b5dbcefdf
出典データセット
uspto-grants-2014_02
特許番号
US08653111B2

反応ノート

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