HCID 59774862、化合物 → HCID 59774864、化合物
反応式
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[CH:12]([C:14]1[S:15][CH:16]=[CH:17][N:18]=1)[OH:13]>ClCCl.O=[Mn]=O>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[C:12]([C:14]1[S:15][CH:16]=[CH:17][N:18]=1)=[O:13]参加物
4
実験手順
A mixture of [2-(methoxymethoxy)-4-methylphenyl](1,3-thiazol-2-yl)methanol from step 1 (3.6 g, 13.7 mmol) and MnO2 (8.28 g, 95.2 mmol) in dichloromethane was stirred at room temperature overnight, filtered, and the insoluble material washed well with boiling EtOAc. The filtrates were combined and concentrated in vacuo to afford the title compound. 1H NMR (400 MHz, acetone-d6): 8.07-8.03 (m, 2H), 7.50 (d, 1H), 7.10 (s, 1H), 6.95 (d, 1H), 5.11 (s, 2H), 3.34 (s, 3H), 2.41 (s, 3H).
後処理
- filtrationfiltered
- washthe insoluble material washed well with boiling EtOAc
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-6fb9d749276242d4bdd1ca62b42ff833
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07960409B2
反応ノート
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