HCID 136085249、化合物 → HCID 135910340、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:26])[C:5]2[CH:6]=[N:7][N:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17]CC4C=CC=CC=4)=[C:13]([F:25])[CH:12]=3)[C:9]=2[CH:10]=1>C(O)C.C(OCC)(=O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([OH:26])[C:5]2[CH:6]=[N:7][N:8]([C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([F:25])[CH:12]=3)[C:9]=2[CH:10]=1参加物
5
実験手順
A solution of 6-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazol-4-ol (D8) (470 mg, 1.34 mmol) in ethanol (20 mL) and ethyl acetate (20 mL) was hydrogenated in an H-cube over a 10% palladium on charcoal catalyst. The resulting solution was concentrated to yield the title compound (E4) (320 mg).
後処理
- concentrationThe resulting solution was concentrated
出典と根拠
- ORDレコード
- ord-7d0df55a58204910b2ca83e8e92e4a99
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07960563B2
反応ノート
読み込み中…