Trifluoroacetic acid → 3-(chlorosulfonyl)-5-fluorobenzoic acid

HRID 2423241ノート

反応式

HRID 2423241 の反応式
FC(F)(F)C(O)=O.[Cl:8][S:9]([C:12]1[CH:13]=[C:14]([CH:25]=[C:26]([F:28])[CH:27]=1)[C:15]([O:17]CC1C=CC=CC=1)=[O:16])(=[O:11])=[O:10]>>[Cl:8][S:9]([C:12]1[CH:13]=[C:14]([CH:25]=[C:26]([F:28])[CH:27]=1)[C:15]([OH:17])=[O:16])(=[O:10])=[O:11]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 86632597HCID 86632597、化合物

生成物 1

HCID 37487043-(chlorosulfonyl)-5-fluorobenzoic acid収率 82.1%

実験手順

A trifluoroacetic acid (18 mL) solution of benzyl 3-(chlorosulfonyl)-5-fluorobenzoate (2.30 g) was stirred at 60° C. for 18 hours. The oily substance floating on the liquid surface was removed, and the solution part was decanted and evaporated under reduced pressure. Hexane was added to the residue, then this was sonicated for 10 minutes. The resulting solid was collected by filtration to obtain 3-(chlorosulfonyl)-5-fluorobenzoic acid (1.37 g). EI: 238

後処理

  1. customwas removed
  2. customthe solution part was decanted
  3. customevaporated under reduced pressure
  4. additionHexane was added to the residue
  5. customthis was sonicated for 10 minutes
  6. filtrationThe resulting solid was collected by filtration

出典と根拠

ORDレコード
ord-1918c54b18684f078d51ca859cc9e109
出典データセット
uspto-grants-2011_06
特許番号
US07960562B2

反応ノート

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