Thionyl Chloride → 3-(Chlorosulfonyl)-5-fluorobenzoyl chloride

HRID 2423242ノート

反応式

HRID 2423242 の反応式
S(Cl)([Cl:3])=O.[Cl:5][S:6]([C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([F:18])[CH:17]=1)[C:12](O)=[O:13])(=[O:8])=[O:7]>CN(C)C=O>[Cl:5][S:6]([C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([F:18])[CH:17]=1)[C:12]([Cl:3])=[O:13])(=[O:8])=[O:7]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 37487043-(chlorosulfonyl)-5-fluorobenzoic acid

生成物 1

HCID 577806583-(Chlorosulfonyl)-5-fluorobenzoyl chloride収率 100.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

反応条件

温度
75 °C

実験手順

One drop of N,N-dimethylformamide was added to a thionyl chloride (2.03 g) suspension of 3-(chlorosulfonyl)-5-fluorobenzoic acid (1.36 g), followed by stirring at 75° C. for 1 hour. The solvent was evaporated, and this was azeotroped with toluene to obtain 3-(chlorosulfonyl)-5-fluorobenzoyl chloride (1.47 g).

後処理

  1. customThe solvent was evaporated
  2. customthis was azeotroped with toluene

出典と根拠

ORDレコード
ord-07191da2f9714a3ca3e72711eca565c4
出典データセット
uspto-grants-2011_06
特許番号
US07960562B2

反応ノート

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