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Ethyl 2-(3-methoxy-4-(5-nitroquinolin-6-yloxy)phenyl)acetate → Ethyl 2-(4-(5-aminoquinolin-6-yloxy)-3-methoxyphenyl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 2-(3-methoxy-4-(5-nitroquinolin-6-yloxy)phenyl)acetate | HCID 59864865 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 2-(4-(5-aminoquinolin-6-yloxy)-3-methoxyphenyl)acetate | HCID 59864773 | — |
反応手順
Pd/C (30 mg) was added to 24.3 (310 mg) in EtOH (10 mL). The mixture was stirred under hydrogen at room temperature for 6 h. The catalyst was removed by filtration through celite. The filtrate was concentrated under vacuum to give 24.4. MS ESI (pos.) m/z: 353.1 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07960567B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-c8724ae8dfef40108eebf9c767ea9de2 |
| 出典メモ | uspto-grants-2011_06 |