Benzyl Alcohol → Benzyl 4-carboxyphenylacetate

反応式

C(C1C=CC(CC(O)=O)=CC=1)=[O:2].C(O)C1C=CC=CC=1.[CH:21]([C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])=[CH:25][CH:24]=1)=[O:22]>>[CH2:33]([O:32][C:30]([CH2:29][C:26]1[CH:25]=[CH:24][C:23]([C:21]([OH:2])=[O:22])=[CH:28][CH:27]=1)=[O:31])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

参加物

反応物 3

HCID 244Benzyl Alcohol

HCID 113441872-(4-formylphenyl)acetic Acid

HCID 19966221Benzyl 2-(4-formylphenyl)acetate

生成物 1

HCID 19966080Benzyl 4-carboxyphenylacetate収率 80.6%

実験手順

Synthesized from (4-formylphenyl)acetic acid (1 g) and benzyl alcohol (730 mg) according to an analogous synthetic method to Example 806, benzyl (4-formylphenyl)acetate (1.4 g) was used according to an analogous synthetic method to Preparation Example 53 to provide the title compound (1.2 g).

後処理

customwas used according to an analogous synthetic method to Preparation Example 53

出典と根拠

ORDレコード: ord-fdfd933d4e5d4a048180ac237136aadb
出典データセット: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07960412B2

反応ノート

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