Aminopyridazine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid PYRIDAZIN-3-YLAMIDE

HRID 2424619

反応式

HRID 2424619 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH2:7])[N:2]=1.[F:8][C:9]([F:34])([F:33])[C:10]1[CH:32]=[CH:31][CH:30]=[CH:29][C:11]=1[C:12]([N:14]1[CH2:19][CH2:18][N:17]([C:20]2[N:25]=[N:24][C:23]([C:26](Cl)=[O:27])=[CH:22][CH:21]=2)[CH2:16][CH2:15]1)=[O:13]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:26]([C:23]2[N:24]=[N:25][C:20]([N:17]3[CH2:16][CH2:15][N:14]([C:12](=[O:13])[C:11]4[CH:29]=[CH:30][CH:31]=[CH:32][C:10]=4[C:9]([F:34])([F:33])[F:8])[CH2:19][CH2:18]3)=[CH:21][CH:22]=2)=[O:27])[N:2]=1

参加物

3

反応物 2

HCID 230373AminopyridazineHCID 865972306-{4-[2-(Trifluoromethyl)benzoyl]piperazin-1-yl}pyridazine-3-carbonyl chloride

生成物 1

HCID 160364416-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid PYRIDAZIN-3-YLAMIDE

実験手順

Following the procedure of Example 28, making variations only as required to use pyridazin-3-ylamine in place of 2-aminopyridine to react with 6-[4-(2-trifluoromethylbenzoyl)-piperazin-1-yl]pyridazine-3-carbonyl chloride, the title compound was obtained as a white powder (17.3% yield). 1H NMR (300 MHz, CDCl3) δ 10.81, 9.05, 8.70, 8.13, 7.87-7.57, 7.39, 6.95, 4.16-3.80, 3.40. C NMR (300 MHz, CDCl3) δ 167.7, 162.3, 160.1, 148.6, 144.1, 132.4, 129.6, 128.1,

出典と根拠

ORDレコード
ord-3f2bfbc04eb14d18be73fb69b44061dc
出典データセット
uspto-grants-2011_06
特許番号
US07964591B2

関連ノート

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