4-tert-Butyl-1,3-thiazol-2-amine → N-(4-tert-butylthiazol-2-yl)-3-(3,4-difluorophenyl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide

HRID 242467

反応式

HRID 242467 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[CH2:29][O:28][CH2:27][CH2:26][C:11]=3[N:12]([C:14](N[C@@H](C(C)(C)C)C(NC)=O)=[O:15])[N:13]=2)[CH:5]=[CH:6][C:7]=1[F:8].[NH2:30][C:31]1[S:32][CH:33]=[C:34]([C:36]([CH3:39])([CH3:38])[CH3:37])[N:35]=1>>[C:36]([C:34]1[N:35]=[C:31]([NH:30][C:14]([N:12]2[C:11]3[CH2:26][CH2:27][O:28][CH2:29][C:10]=3[C:9]([C:4]3[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=3)=[N:13]2)=[O:15])[S:32][CH:33]=1)([CH3:39])([CH3:38])[CH3:37]

参加物

3

反応物 2

HCID 27342024-tert-Butyl-1,3-thiazol-2-amineHCID 46834697(S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methyl-amino)-1-oxobutan-2-yl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide

生成物 1

HCID 46830659N-(4-tert-butylthiazol-2-yl)-3-(3,4-difluorophenyl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide

実験手順

Compound 56 was prepared according to the procedure described for the synthesis of compound 28 by replacing tert-leucine methylamide with 2-amino-4-tert-butylthiazole. LCMS (+ESI) m/z=419.2 [M+H]+.

出典と根拠

ORDレコード
ord-5ae4b90e57fe4e0e8d17b3622fcd3b34
出典データセット
uspto-grants-2014_02
特許番号
US08653127B2

関連ノート

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