1,4-Dioxaspiro[4.5]decan-8-one → (S)-3'-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6',7'-dihydrospiro[[1,3]dioxolane-2,5'-indazole]-1'(4'H)-carboxamide

HRID 242469

反応式

HRID 242469 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[CH2:29]O[CH2:27][CH2:26][C:11]=3[N:12]([C:14]([NH:16][C@@H:17]([C:22]([CH3:25])([CH3:24])[CH3:23])[C:18]([NH:20][CH3:21])=[O:19])=[O:15])[N:13]=2)[CH:5]=[CH:6][C:7]=1[F:8].[O:30]1[C:34]2(CCC(=O)CC2)[O:33][CH2:32][CH2:31]1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[CH2:29][C:34]4([O:33][CH2:32][CH2:31][O:30]4)[CH2:27][CH2:26][C:11]=3[N:12]([C:14]([NH:16][C@@H:17]([C:22]([CH3:23])([CH3:25])[CH3:24])[C:18]([NH:20][CH3:21])=[O:19])=[O:15])[N:13]=2)[CH:5]=[CH:6][C:7]=1[F:8]

参加物

3

反応物 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 46834697(S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methyl-amino)-1-oxobutan-2-yl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide

生成物 1

HCID 46863561(S)-3'-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6',7'-dihydrospiro[[1,3]dioxolane-2,5'-indazole]-1'(4'H)-carboxamide

実験手順

Compound 63 was prepared according to the procedure described for the synthesis of compound 28 by replacing tetrahydro-4H-pyran-4-one with 1,4-dioxaspiro[4.5]decan-8-one in the synthesis of intermediate 16. LCMS (+ESI) m/z=463.2 [M+H]+.

出典と根拠

ORDレコード
ord-c9207b47074646b6868c0269712be68e
出典データセット
uspto-grants-2014_02
特許番号
US08653127B2

関連ノート

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