(R)-beta-aminophenethyl alcohol → HCID 46861921、化合物

HRID 242475

反応式

HRID 242475 の反応式
C[C:2]([CH3:31])([CH3:30])[C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][N:16]([CH3:20])[CH2:15][C:14]=2[C:13]([C:21]2[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:22]=2[F:29])=[N:12]1)=[O:10])[C:4](NC)=[O:5].N[C@H:33]([C:36]1C=CC=CC=1)[CH2:34]O>>[OH:5][CH2:4][C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][N:16]([CH3:20])[CH2:15][C:14]=2[C:13]([C:21]2[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:22]=2[F:29])=[N:12]1)=[O:10])[C:2]1[CH:30]=[CH:36][CH:33]=[CH:34][CH:31]=1

参加物

3

反応物 2

HCID 2724025(R)-beta-aminophenethyl alcoholHCID 46863441(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

生成物 1

HCID 46861921HCID 46861921、化合物

実験手順

Compound 70 was prepared according to the procedure described for the synthesis of compound 37 by replacing tert-leucine methylamide with (R)-2-amino-2-phenylethanol. LCMS (+ESI) m/z=431.2 [M+H]+.

出典と根拠

ORDレコード
ord-eeb770535cec4d84a4178574c37732ef
出典データセット
uspto-grants-2014_02
特許番号
US08653127B2

関連ノート

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