Iodoethane → 4-(1,1-Dimethylethyl)-2-ethoxy-1-iodobenzene

HRID 2425578ノート

反応式

HRID 2425578 の反応式
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([I:12])=[C:9]([OH:11])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:19](I)[CH3:20]>C(O)C.C(OCC)C>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([I:12])=[C:9]([O:11][CH2:19][CH3:20])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 117478025-tert-Butyl-2-iodophenol

生成物 1

HCID 672460864-(1,1-Dimethylethyl)-2-ethoxy-1-iodobenzene収率 99%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

The mixture of 5-tert-butyl-2-iodo-phenol (132.7 g, 480.6 mmol), potassium carbonate (265.7 g, 1923 mmol) and ethyl iodide (76.9 mL, 961.3 mmol) in ethanol (1.125 mL) was heated at reflux overnight. Upon cooling to room temperature, the reaction mixture was diluted with diethyl ether. The white solids were filtered off, and the filtrate was concentrated in vacuo to give 4-tert-butyl-2-ethoxy-1-iodo-benzene (144.7 g) as pale yellow oil.

後処理

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. filtrationThe white solids were filtered off
  4. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-73f996cd49394a1ba2d7b43b916c9472
出典データセット
uspto-grants-2011_06
特許番号
US07964724B2

反応ノート

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