Sodium Chloride → 5-(2-Cyanobutanoyl)thiophene-2-carbohydrazide

HRID 2425941ノート

反応式

HRID 2425941 の反応式
[C:1]([CH:3]([CH2:15][CH3:16])[C:4]([C:6]1[S:10][C:9]([C:11](OC)=[O:12])=[CH:8][CH:7]=1)=[O:5])#[N:2].[OH-].[K+].O.[NH2:20][NH2:21].[Cl-].[Na+]>CO>[C:1]([CH:3]([CH2:15][CH3:16])[C:4]([C:6]1[S:10][C:9]([C:11]([NH:20][NH2:21])=[O:12])=[CH:8][CH:7]=1)=[O:5])#[N:2]

参加物

6

反応物 4

HCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 67087195Methyl 5-(2-cyanobutanoyl)thiophene-2-carboxylate

生成物 1

HCID 670873785-(2-Cyanobutanoyl)thiophene-2-carbohydrazide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Methyl 5-(2-cyanobutyryl)thiophene-2-carboxylate (213 mg, 0.90 mmol) in methanol was stirred with 0.1 M potassium hydroxide in methanol (9.0 mL, 0.90 mmol) at room temperature for 10 minutes and then with hydrazine monohydrate (225 mg, 4.50 mg) at 80° C. for 6 hours. After addition of saturated aqueous sodium chloride, the reaction solution was extracted with ethyl acetate, dried over anhydrous magnesium sulfate and concentrated to give the crude desired product.

後処理

  1. extractionthe reaction solution was extracted with ethyl acetate
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-9b5ebb64dfaa4e4ea0cc52ddc7ad69e1
出典データセット
uspto-grants-2011_06
特許番号
US07968542B2

反応ノート

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