1-(Benzyloxy)piperidin-2-imine hydrochloride → 2-Iminopiperidin-1-ol hydrochloride
反応式
[ClH:1].C([O:9][N:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C:11]1=[NH:16])C1C=CC=CC=1>CO.[Pd]>[ClH:1].[NH:16]=[C:11]1[CH2:12][CH2:13][CH2:14][CH2:15][N:10]1[OH:9]参加物
4
実験手順
A solution of 1-(benzyloxy)piperidin-2-imine hydrochloride in methanol, containing palladium on charcoal (10%, w/w) was stirred under hydrogen at atmospheric pressure for 3 h. The catalyst was filtered off and the solution was concentrated to dryness under reduced pressure. The residue was triturated with diethyl ether, filtered and dried under high vacuum to afford 2-iminopiperidin-1-ol hydrochloride as a pale yellow solid.
後処理
- filtrationThe catalyst was filtered off
- concentrationthe solution was concentrated to dryness under reduced pressure
- customThe residue was triturated with diethyl ether
- filtrationfiltered
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-55a0272b94474826aa3f96bebcdf12a9
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07968553B2
反応ノート
読み込み中…