Trifluoroacetic acid → (R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]amine

HRID 2426616ノート

反応式

HRID 2426616 の反応式
[CH3:1][N:2]([C@@H:10]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)[CH2:11]1)C(=O)OC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:1][NH:2][C@@H:10]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)[CH2:11]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67148139tert-Butyl (R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]carbamate

生成物 1

HCID 67147986(R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of tert-butyl (R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]-carbamate (0.7 g) in dichloromethane (5 ml) was treated with trifluoroacetic acid (3 ml) for 1 hour. The reaction solution was concentrated and the residue was taken up in dichloromethane. After washing with sodium carbonate solution, the organic phase was dried over magnesium sulfate and concentrated. This resulted in the product with the molecular weight of 221.26 (C11H15N3O2); MS (ESI): 222 (M+H+).

後処理

  1. concentrationThe reaction solution was concentrated
  2. washAfter washing with sodium carbonate solution
  3. dry with materialthe organic phase was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customThis resulted in the product with the molecular weight of 221.26 (C11H15N3O2)

出典と根拠

ORDレコード
ord-a1cad2989745491893a193ee15e3f6dd
出典データセット
uspto-grants-2011_06
特許番号
US07968550B2

反応ノート

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