Hydrochloric Acid → 5-Chloro-1',2',3',6'-tetrahydro-2,4'-bipyridine

HRID 2426692ノート

反応式

HRID 2426692 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH2:9][CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH:13]=2)=[N:6][CH:7]=1.Cl>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH:13]=2)=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21105685tert-butyl 4-(5-chloro-2-pyridyl)-3,6-dihydro-2H-pyridine-1-carboxylate

生成物 1

HCID 211055245-Chloro-1',2',3',6'-tetrahydro-2,4'-bipyridine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of tert-butyl 5-chloro-3′,6′-dihydro-2′H-[2,4′]bipyridine-1′-carboxylate (50 mg) in chloroform (2.4 ml) was mixed with hydrogen chloride (4N in dioxane; 0.8 ml) and the mixture was concentrated after 13 hours. This resulted in the product with the molecular weight of 194.67 (C10H11CIN2); MS (ESI): 195 (M+H+).

後処理

  1. concentrationthe mixture was concentrated after 13 hours
  2. customThis resulted in the product with the molecular weight of 194.67 (C10H11CIN2)

出典と根拠

ORDレコード
ord-c1708b442af44f52b0c77cc21be7e2f9
出典データセット
uspto-grants-2011_06
特許番号
US07968550B2

反応ノート

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