Acetic Anhydride → 4-(3-Acetylaminophenyl)benzoic acid

HRID 2426726ノート

反応式

HRID 2426726 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>N1C=CC=CC=1>[C:17]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1)(=[O:19])[CH3:18]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 27563554-(3-aminophenyl)benzoic Acid

生成物 1

HCID 200999844-(3-Acetylaminophenyl)benzoic acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

3′-Aminobiphenyl-4-carboxylic acid (0.2 g) was mixed with pyridine (0.7 g) and acetic anhydride (180 mg) and, after 14 hours, volatile fractions were removed. The residue was taken up in sodium hydroxide solution (2N) and washed with diethyl ether. The aqueous phase was acidified with hydrochloric acid and extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. This resulted in the product with the molecular weight of 255.28 (C15H13NO3); MS (ESI): 256 (M+H+).

後処理

  1. customvolatile fractions were removed
  2. washwashed with diethyl ether
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic phase was dried over magnesium sulfate
  5. concentrationconcentrated
  6. customThis resulted in the product with the molecular weight of 255.28 (C15H13NO3)

出典と根拠

ORDレコード
ord-d802fe5c72d144c09f9dcb5b8921f9f1
出典データセット
uspto-grants-2011_06
特許番号
US07968550B2

反応ノート

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