5-Benzyl-octahydropyrrolo(3,4-c)pyrrole-1,3-dione → Perhydropyrrolo(3,4-c)pyrrole-1,3-dione

HRID 2426866

反応式

HRID 2426866 の反応式
C([N:8]1[CH2:12][CH:11]2[C:13](=[O:17])[NH:14][C:15](=[O:16])[CH:10]2[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[C:13]1(=[O:17])[CH:11]2[CH2:12][NH:8][CH2:9][CH:10]2[C:15](=[O:16])[NH:14]1

参加物

4

反応物 1

HCID 45649025-Benzyl-octahydropyrrolo(3,4-c)pyrrole-1,3-dione

生成物 1

HCID 21476587Perhydropyrrolo(3,4-c)pyrrole-1,3-dione

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution 5-benzyl-tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione, (11.5 g; 49.9 mmol) in ethanol (200 ml) is placed in a ml autoclave and palladium-on-charcoal (5%; 2 g; 0.9 mmol) is then added. After having purged the reactor with nitrogen, the autoclave is placed under 58 bars of hydrogen at 70° C. for 16 hours. After returning to 20° C., filtration and washing of the catalyst, evaporation is carried out under reduced pressure and the solid obtained is then recrystallized from methanol (100 ml) and drying is carried out under reduced pressure at constant weight. Perhydropyrrolo[3,4-c]pyrrole-1,3-dione, (3.6 g) is isolated, the characteristics of which are as follows:

後処理

  1. additionis then added
  2. customAfter having purged the reactor with nitrogen
  3. customAfter returning to 20° C.
  4. filtrationfiltration
  5. washwashing of the catalyst, evaporation
  6. customthe solid obtained
  7. customis then recrystallized from methanol (100 ml)
  8. customdrying

出典と根拠

ORDレコード
ord-f93aa7a6574345048f6373726ffc03c4
出典データセット
uspto-grants-2011_06
特許番号
US07968566B2

関連ノート

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