Water → 4-(2-Hydroxyacetyl)benzonitrile

HRID 2427141ノート

反応式

HRID 2427141 の反応式
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4].[OH2:13]>C(#N)C>[OH:13][CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4]

参加物

4

反応物 2

HCID 962WaterHCID 986544-(Bromoacetyl)benzonitrile

生成物 1

HCID 179928864-(2-Hydroxyacetyl)benzonitrile

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 1 g of 4-(2-bromoacetyl)benzonitrile in acetonitrile (5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min) The same experiment is conducted five times. All the vials are collected, extracted with ethyl ether, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

後処理

  1. customAll the vials are collected
  2. extractionextracted with ethyl ether
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-fc19a66bb1db4d53855eabf0420fa6a8
出典データセット
uspto-grants-2011_06
特許番号
US07968581B2

反応ノート

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