Benzoyl Peroxide → 5-Bromo-2-(bromomethyl)-1,3-dichlorobenzene
反応式
[Br:1][C:2]1[CH:3]=[C:4]([Cl:10])[C:5]([CH3:9])=[C:6]([Cl:8])[CH:7]=1.[Br:11]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH2:9][Br:11])=[C:4]([Cl:10])[CH:3]=1参加物
5
実験手順
Heat a solution of 5-bromo-1,3-dichloro-2-methylbenzene (97 mg, 0.40 mmol), N-bromosuccinimide (76 mg, 0.425 mmol) and benzoyl peroxide (16 mg, 0.06 mmol) in CCl4 (5 mL) to reflux for 3 hours under N2. Cool the reaction to room temperature and concentrate to an orange residue. Purify the residue by silica gel chromatography eluting with hexanes to afford 112 mg (87%) of the product as white crystals.
後処理
- temperatureto reflux for 3 hours under N2
- temperatureCool
- customthe reaction to room temperature
- concentrationconcentrate to an orange residue
- customPurify the residue by silica gel chromatography
- washeluting with hexanes
出典と根拠
- ORDレコード
- ord-56bc74df5037491aa0512ac34fab2992
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07968585B2
反応ノート
読み込み中…