Benzoyl Peroxide → 5-Bromo-2-(bromomethyl)-1,3-dichlorobenzene

HRID 2427460

反応式

HRID 2427460 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([Cl:10])[C:5]([CH3:9])=[C:6]([Cl:8])[CH:7]=1.[Br:11]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH2:9][Br:11])=[C:4]([Cl:10])[CH:3]=1

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 6411555-Bromo-1,3-dichloro-2-methylbenzene

生成物 1

HCID 594744985-Bromo-2-(bromomethyl)-1,3-dichlorobenzene収率 87.8%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

Heat a solution of 5-bromo-1,3-dichloro-2-methylbenzene (97 mg, 0.40 mmol), N-bromosuccinimide (76 mg, 0.425 mmol) and benzoyl peroxide (16 mg, 0.06 mmol) in CCl4 (5 mL) to reflux for 3 hours under N2. Cool the reaction to room temperature and concentrate to an orange residue. Purify the residue by silica gel chromatography eluting with hexanes to afford 112 mg (87%) of the product as white crystals.

後処理

  1. temperatureto reflux for 3 hours under N2
  2. temperatureCool
  3. customthe reaction to room temperature
  4. concentrationconcentrate to an orange residue
  5. customPurify the residue by silica gel chromatography
  6. washeluting with hexanes

出典と根拠

ORDレコード
ord-56bc74df5037491aa0512ac34fab2992
出典データセット
uspto-grants-2011_06
特許番号
US07968585B2

関連ノート

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