Sodium Hydroxide → HCID 57949645、化合物

HRID 2427495ノート

反応式

HRID 2427495 の反応式
[Br:1][C:2]1[CH:9]=[C:8]([CH3:10])[C:5]([C:6]#[N:7])=[C:4]([O:11][CH3:12])[CH:3]=1.[OH-:13].[Na+]>CO>[Br:1][C:2]1[CH:9]=[C:8]([CH3:10])[C:5]([C:6]([NH2:7])=[O:13])=[C:4]([O:11][CH3:12])[CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 454803844-bromo-2-methoxy-6-methylbenzonitrile

生成物 1

HCID 57949645HCID 57949645、化合物収率 90%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-Bromo-2-methoxy-6-methyl benzonitrile (7.3 g, 32.4 mmol) was stirred in MeOH (100 mL) and 5N NaOH (100 mL) at 100° C. for 12 hours. The reaction was cooled to room temperature and the methanol was removed under reduced pressure. The reaction mixture was extracted with CH2Cl2 and the solvent was removed under reduced pressure to yield the product (7.13 g, 90%). 1H NMR (300 MHz, CDCl3): δ 7.03 (d, 1H), 6.94 (d, 1H), 5.83 (br s, 2H), 3.85 (s, 3H), 2.39 (s, 3H).

後処理

  1. customthe methanol was removed under reduced pressure
  2. extractionThe reaction mixture was extracted with CH2Cl2
  3. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-d43eeb57947f49f49ffdc57d393ffec6
出典データセット
uspto-grants-2011_06
特許番号
US07968570B2

反応ノート

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