m-Chloroperbenzoic acid → Methyl thieno[3,4-b]thiophene-2-carboxylate

HRID 242764ノート

反応式

HRID 242764 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:9][C:8]2[CH2:10][S:11][CH2:12][C:7]=2[CH:6]=1)=[O:4].C1C=C(Cl)C=C(C(OO)=O)C=1>C(OCC)(=O)C.C(=O)=O>[S:9]1[C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][C:7]2=[CH:12][S:11][CH:10]=[C:8]12

参加物

5

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 3441857Methyl 4,6-dihydrothieno[3,4-b]thiophene-2-carboxylate

生成物 1

HCID 19007653Methyl thieno[3,4-b]thiophene-2-carboxylate

試薬・触媒・溶媒 2

HCID 280Carbon Dioxide溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

A solution of 2.0 g (10 mmol) (3) in 30 mL ethyl acetate was stirred and cooled down in dry ice bath. MCPBA (1.75 g, 10 mmol) in 30 mL ethyl acetate was added dropwise to the reaction solution. After the addition, the mixture was kept stirring for overnight. Then the solvent was removed by evaporation and the residue contained a crude product of (4) and 3-chlorobenzoic acid.

後処理

  1. additionAfter the addition
  2. customThen the solvent was removed by evaporation

出典と根拠

ORDレコード
ord-c57d31ad389d49c883de7ca97a887f21
出典データセット
uspto-grants-2014_02
特許番号
US08653228B2

反応ノート

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