Benzoyl Peroxide → Methyl 4-bromo-2-(bromomethyl)-6-chlorobenzoate

HRID 2427645ノート

反応式

HRID 2427645 の反応式
[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([CH3:10])=[CH:8][C:7]([Br:11])=[CH:6][C:5]=1[Cl:12].[Br:14]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:5]([Cl:12])=[CH:6][C:7]([Br:11])=[CH:8][C:9]=1[CH2:10][Br:14]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 45480505Methyl 4-bromo-2-chloro-6-methylbenzoate

生成物 1

HCID 59512234Methyl 4-bromo-2-(bromomethyl)-6-chlorobenzoate

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of 4-bromo-2-chloro-6-methyl-benzoic acid methyl ester (2.447 g, 9.27 mmol,), N-bromosuccinimide (1.815 g, 10.2 mmol), and benzoyl peroxide (0.051 g, 0.22 mmol) in carbon tetrachloride (30 mL) was refluxed until most of the starting materials were consumed (as analyzed by GC/MS). The resulting mixture was filtered and the filtrate concentrated to afford 4-bromo-2-bromomethyl-6-chloro-benzoic acid methyl ester. The product was used without further purification.

後処理

  1. temperaturewas refluxed until most of the starting materials
  2. customwere consumed (as analyzed by GC/MS)
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-3cfd6acd75324c6e98fe2e700e3d8aa4
出典データセット
uspto-grants-2011_06
特許番号
US07968570B2

反応ノート

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