3-Nitro-N-(pyridin-2-yl)pyridin-2-amine → 2-(2-Pyridylamino)-3-amino-pyridine
反応式
[N+:1]([C:4]1[C:5]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].CCOC(C)=O>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[NH:10][C:5]1[C:4]([NH2:1])=[CH:9][CH:8]=[CH:7][N:6]=1参加物
4
反応条件
- 温度
- 20 °C
実験手順
A mixture of (3-nitro-pyridin-2-yl)-pyridin-2-yl-amine (0.84 g, 3.89 mmol) and 10% palladium on carbon (0.30 g) in EtOAc (20 mL) was stirred under an atmosphere of hydrogen at atmospheric pressure and 20° C. for 16 h. The catalyst was removed by filtration and the filtrate concentrated in vacuo to give the title compound as a green solid (0.63 g, 88%). LCMS (method H): Rt 1.87 min, [M+H]+ 187.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-bcc87e67b36a4042aaf1fab5ae2e4191
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08653089B2
反応ノート
読み込み中…