5-Fluoroisatin → 5-fluoro-1,3-dihydro-2H-indol-2-one

HRID 24307

反応式

HRID 24307 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O>O.NN>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2

参加物

3

反応物 1

HCID 2365665-Fluoroisatin

生成物 1

HCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

試薬・触媒・溶媒 1

HCID 24654Hydrazine hydrate (1:1)溶媒

実験手順

5-Fluoroisatin (8.2 g) was dissolved in 50 mL of hydrazine hydrate and refluxed for 1.0 hr. The reaction mixtures were then poured in ice water. The precipitate was then filtered, washed with water and dried in a vacuum oven to afford the title compound.

後処理

  1. temperaturerefluxed for 1.0 hr
  2. customThe reaction mixtures
  3. filtrationThe precipitate was then filtered
  4. washwashed with water
  5. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-85f8d0a13c1741908216e141c66ffd9d
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

関連ノート

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