Trifluoroacetic acid → HCID 178511745、化合物
反応式
C(OC(=O)[NH:7][C@H:8]1[CH2:11][C@H:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:13]([O:12][C@H:10]1[CH2:11][C@H:8]([NH2:7])[CH2:9]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1参加物
4
実験手順
To a solution of (trans-3-benzyloxycyclobutyl)carbamic acid tert-butyl ester (0.99 g, 3.56 mmol) in DCM (10 mL) was added TFA (2 mL) and the mixture stirred at RT for 3 h. The volatiles were removed in vacuo and the resulting residue dissolved in DCM and loaded onto an SCX-2 (20 g) cartridge. The cartridge was washed with DCM then MeOH and then 2M NH3 in MeOH solution. The relevant fractions were concentrated in vacuo to afford the title compound as yellow oil (0.6 g, quantitative). 1H NMR (CDCl3, 400 MHz): δ 7.36-7.31 (5H, m), 4.40 (2H, s), 4.29-4.20 (1H, m), 3.75-3.65 (1H, m), 2.39-2.26 (2H, m), 2.02-1.90 (2H, m), 1.49 (2H, s, br).