Sodium Hydroxide → 6-Amino-1,3-dihydro-2H-indol-2-one

HRID 24345

反応式

HRID 24345 の反応式
O.O.[Sn](Cl)(Cl)(Cl)Cl.[N+:8]([C:11]1[CH:16]=[C:15]([N+:17]([O-])=O)[CH:14]=[CH:13][C:12]=1[CH2:20][C:21]([OH:23])=O)([O-])=O.[OH-].[Na+]>C(O)C>[NH2:17][C:15]1[CH:16]=[C:11]2[C:12]([CH2:20][C:21](=[O:23])[NH:8]2)=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 2215132,4-Dinitrophenylacetic acidHCID 85782573Tin tetrachloride dihydrate

生成物 1

HCID 5905386-Amino-1,3-dihydro-2H-indol-2-one収率 101.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

Tin chloride dihydrate (225 g) was added to a solution of 2,4-dinitrophenylacetic acid (22.6 g) in ethanol (450 ml). The mixture was heated at 90° C. for 10 hours. The reaction mixture was cooled and adjusted to pH 11 with 12M sodium hydroxide. The solids were removed by filtration and the filtrate was concentrated. The residue was treated with ethanol (300 ml). Insoluble materials were removed by filtration and washed with ethanol (5×60 ml). The combined ethanol solutions were evaporated and the solid obtained was dried under vacuum to give 15 g of 6-amino-2-oxindole as a brown powder.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customThe solids were removed by filtration
  3. concentrationthe filtrate was concentrated
  4. additionThe residue was treated with ethanol (300 ml)
  5. customInsoluble materials were removed by filtration
  6. washwashed with ethanol (5×60 ml)
  7. customThe combined ethanol solutions were evaporated
  8. customthe solid obtained
  9. customwas dried under vacuum

出典と根拠

ORDレコード
ord-495d6f7339d542228f12d5bb89aa27ff
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

関連ノート

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